Apr 25 2009

Researchers Create AMD Prediction Model

Published by at 8:38 pm under Macular degeneration

Researchers from Tufts University have created a model to better predict a person’s risk for Age-related Macular Degeneration (AMD). 

This study, published in the May issue of Investigative Ophthalmology and Visual Science, was based on data from the 1,446 participants in the Age-Related Eye Disease Study (AREDS).  It shows how genetic, ocular, and environmental variables were evaluated and predictive models for prevalence and incidence of AMD were assessed. 

Researchers evaluated six criteria:

  • age,
  • sex,
  • education,
  • smoking status,
  • body mass index, and
  • supplementation with high-dose formulation of antioxidants and zinc (to slow progression of the AMD).

Although genetics play a large part in who will get AMD, there are lifestyle choices that can greatly influence a person’s risks for AMD.  Dr. Seddon noted that among individuals with one genotype studied (homozygous C3 risk genotype), the chance of suffering from the advanced form of AMD increased from approximately three times the risk for nonsmokers to almost 10 times the risk for smokers.

Study authors hope that learning more about how to predict who is at risk for AMD will give doctors and patients better information about how to better treat and even help prevent AMD.

Learn more about AMD and AMD prevention self-help tips

SOURCE:  Prediction Model for Prevalence and Incidence of Advanced Age-Related Macular Degeneration Based on Genetic, Demographic, and Environmental Variables, Seddon, et al, Investigative Ophthalmology and Visual Science. 2009;50:2044-2053.

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