Dr. Grossman’s Blog

Can something as easy as taking a daily multi-vitamin help prevent cataracts? Researchers believe it can!

An analysis of Age-Related Eye Disease Study (AREDS) data has found that consistent use of a multi-vitamin and mineral supplement may delay the progression of age-related lens opacities.  Lens opacities in the form of cataracts are the leading cause of blindness around the world today.

Of the 4596 participants enrolled in the AREDS cataract trial, approximately two-thirds elected to take a multi-vitamin supplement containing RDA-recommended levels of vitamins and minerals.

Subjects were assessed for development or progression of lens opacities via lens photographs at baseline and at annual visits beginning at year 2.  Statistics were collected on changes in amounts of nuclear, cortical, or posterior subcapsular opacity, or the performance of cataract surgery.

Researchers found the risk of development of or progression to any cataract was reduced by 16% in regular multi-vitamin takers. For nuclear cataract, a 25% risk reduction was observed in the multi-supplement users.

Read more about cataracts, including recommended vitamins and supplements

SOURCE:  “Centrum Use and Progression of Age-Related Cataract in AREDS”, AREDS Research Group, Ophthalmol 113:1264-0, 2006.

Antioxidants not only help prevent some eye diseases, they may also help limit progression of the diseases

It’s known that taking antioxidants helps delay the onset of some eye diseases associated with aging, such as cataract. Now researchers believe that antioxidants can be effective if damage to retinal tissue has already set in.

Researchers at the University of Maryland School of Medicine studied the effects of reactive oxygen species (ROS)-induced damage to retinal tissue. An increase in ROS levels can result in significant damage to cell structures — a situation known as oxidative stress. Oxidative stress is a significant risk factor in the development of many eye diseases associated with aging.

Since the formation of cataract is a well-defined progressive disease, believed to be related to a continued generation of ROS in the aqueous humor, the researchers hypothesized that even a late start with an appropriate antioxidant could halt the process and delay cataract development and vision impairment.

The results? Adding pyruvate – known to be an effective ROS scavenger — to lens cultures after lenses had sustained 50% damage was significantly effective in preventing progress.

Pyruvate can be found in foods such as red apples, and to a lesser extent, in dark beer and some cheeses.

Learn more about antioxidants

Read more about antioxidants and their importance in maintaining healthy vision

SOURCE:  “Oxidative damage to lens in culture: reversibility by pyruvate and ethyl pyruvate”, Varma, et al, Ophthalmologica, 2008; 222 (3):194-198.

My posting of May 28, 2008 referenced N-Acetyl-Carnosine, which can stabilize and even improve cataracts.

Carnosine’s best-known effect, however, is its ability to prevent the formation of advanced glycated end products (protein crosslinks). Carnosine competes with proteins for the binding sites they would occupy on sugar molecules, making it the best glycation preventative currently recognized in the world of nutrition research. Carnosine has been found to significantly extend the life span of cultured cells and fruit flies, inhibit the toxic effects of the protein that accumulates in the brains of Alzheimer’s patients, protect against the toxic effects of copper- zinc in the brain and enhance the state of balance (homeostasis) under which physiological systems work best. And, finally, it has been shown to prevent and/or reverse cataract.14,1514. Quinn PJ, et al. Carnosine: its properties, functions and potential therapeutic applications. Mol Aspects Med 1992; 13(5):379-444. 15. Specht S, et al. Continuing damage to rat retinal DNA during darkness following light exposure. Photochem Photobiol 2000; 71(5):559-66.

When administered topically to the eye in the form of N-acetyl-L-carnosine-(functionally, a time-release form of carnosine), this dipeptide can move easily into both the water-soluble (aqueous) and lipid-containing parts of the eye. Once there, it helps to prevent DNA strand breaks induced by UV radiation and enhances DNA repair.16 Once it has entered the lipid areas of the eye, N-acetyl-L-carnosine partially breaks down and becomes L-carnosine.

Chinese and Russian researchers have studied cataract-preventive nutrients for nearly a decade. A Chinese study done by A.M. Wang in 1999, used 96 patients aged 60 years or older having senile cataracts of various degrees of maturity with the duration of the disease from 2 to 21 years. Patients instilled one to two drops of the carnosine-containing solution in each eye three to four times each day for a period of treatment ranging from three to six months. The level of eyesight improvement and the change of lens transparency were considered as an evaluation index of the curative effect of carnosine. The result showed that carnosine gives a pronounced effect on primary senile cataracts, the effective rate being 100%. For mature senile cataracts, the effect rate was 80%.

Ref: Wang AM, et al. Use of carnosine as a natural anti-senescence drug for human beings. Department of Biochemistry and Department of Neurobiology, Harbin Medical University, China 1999.

This study showed that using eyedrops containing n-acetyl-carnosine can stabilize and even improve cataracts.

Statistical analysis revealed the significant differences over 6 and 24 months in cumulative positive changes of overall characteristics of cataracts in the NAC-treated Group II from the control Group I. The N-acetylated form of natural dipeptide L-carnosine appears to be suitable and physiologically acceptable for nonsurgical treatment for senile cataracts.

Peptides 2001 Jun;22(6):979-94

See more information on cataracts and nutrition.