Dr. Grossman’s Blog

Click on the link below for a short inteview done by Leslie Degner, RN, BSN with Dr. Grossman regarding eye exercises related to healthy vision and macular degeneration:

http://www.webrn-maculardegeneration.com/free-eye-exercises.html

Editor’s Note: For Dr. Grossman’s free eye exercise e-booklet, go to http://www.naturaleyecare.com/eye-sample.asp

A new study now reports that pine bark extract (which contains procyanidins) may extend vision-saving benefits to diabetics with early stage retinopathy by improving retinal blood flow and inducing regression of edema.

It is estimated that between 40 and 50% of Americans diagnosed with diabetes already have some stage of diabetic retinopathy, according to the National Institutes of Health.

Reference: Steigerwalt R, et al. Pycnogenol® improves microcirculation, retinal edema, and visual acuity in early diabetic retinopathy. J Ocular Pharmacol Therap 25:537-40, 2009.

Editor’s Note: For an excellent whole food eye formula with Pine Bark Extract, see Dr. Grossman’s Advanced Eye and Vision Support

A 2007 study showed the low levels of Vitamin D3 is linked to an increase in the pevalence of macular degeneration.

Ref: Parekh N, Chappell RJ, Millen AE, Albert DM, Mares JA. Association Between Vitamin D and Age-Related Macular Degeneration in the Third National Health and Nutrition Examination Survey, 1988 Through 1994. Arch Ophthalmol. May 2007;125: 661-669.

Editor’s Note: For more related studies on nutrition and macular degeneration, go to www.naturaleyecare.com/studies_bydisease.asp?s_num=8&disease=Macular+Degeneration

Lutein and zeaxanthin are carotenoids used in the retina and lens of the eyes. These are antioxidants that color yellow and leafy dark green vegetables such as kale, spinach, and carrots. Researchers believe that this pair of antioxidants may help build and maintain the pigment layer of the retina. Another theory is that they help filter out blue light, protecting the eye from sunlight damage.

Studies have shown that these antioxidants can help us preserve healthy vision, and significantly reduce the risk of onset of macular degeneration and cataracts.

References:

Women’s Health Study. Archives of Ophthalmology (Arch. Ophthalmol. 2008;126:102-9)

Moeller SM et al. Age-Related Macular Degeneration and Lutein and Zeaxanthin in the Carotenoids in Age-Related Eye Disease Study (CAREDS). Archives of Ophthalmology 124:1151-1162, 2006.

Editor’s Note: For more related studies, go to www.naturaleyecare.com/studylist.asp

Researchers from Tufts University have created a model to better predict a person’s risk for Age-related Macular Degeneration (AMD). 

This study, published in the May issue of Investigative Ophthalmology and Visual Science, was based on data from the 1,446 participants in the Age-Related Eye Disease Study (AREDS).  It shows how genetic, ocular, and environmental variables were evaluated and predictive models for prevalence and incidence of AMD were assessed. 

Researchers evaluated six criteria:

• age,
• sex,
• education,
• smoking status,
• body mass index, and
• supplementation with high-dose formulation of antioxidants and zinc (to slow progression of the AMD).

Although genetics play a large part in who will get AMD, there are lifestyle choices that can greatly influence a person’s risks for AMD.  Dr. Seddon noted that among individuals with one genotype studied (homozygous C3 risk genotype), the chance of suffering from the advanced form of AMD increased from approximately three times the risk for nonsmokers to almost 10 times the risk for smokers.

Study authors hope that learning more about how to predict who is at risk for AMD will give doctors and patients better information about how to better treat and even help prevent AMD.

Learn more about AMD and AMD prevention self-help tips

SOURCE:  Prediction Model for Prevalence and Incidence of Advanced Age-Related Macular Degeneration Based on Genetic, Demographic, and Environmental Variables, Seddon, et al, Investigative Ophthalmology and Visual Science. 2009;50:2044-2053.

Antioxidant and omega-3 supplements continue to be a simple, low-cost, effective therapy for AMD

A study designed to measure changes in visual function in subjects with atrophic (dry) age-related macular degeneration (AMD) found that three-quarters of the subjects receiving a nutritional supplement demonstrated stabilization or improvement of visual acuity at 6 months.

Dry, atrophic, or non-exudative, AMD is the most common form of macular degeneration.  Risk factors for dry AMD include:

• age greater than 50
• Caucasian race
• poor nutrition
• smoking
• atherosclerotic vascular disease
• genetics 
• sunlight exposure.

Multiple studies have suggested that nutritional factors can play a significant role in slowing the onset or limiting the effects of AMD.  The Taurine, Omega-3 Fatty Acids, Zinc, Antioxidant, Lutein (TOZAL) study tried to identify the potential benefits of a new supplement designed to limit the risk of AMD and progressive vision loss.

In this study, published in BMC Ophthalmology, 37 mixed gender patients (average age 76 years) at 5 independent study sites received a nutritional supplement specifically formulated to combat AMD.   This supplement included natural beta-carotene, vitamins A and E, zinc, and copper.   Results were compared to subjects in other tests who had been given placebos.

76.7% of subjects receiving the nutritional supplement demonstrated stabilization or improvement of visual acuity at 6 months.

Read other studies about AMD

Learn more about antioxidants and food sources for nutrients important for good eye health

SOURCE:  TOZAL Study: An open case control study of an oral antioxidant and omega-3 supplement for dry AMD, Cangemi, BMC Ophthalmology 2007, 7:3doi:10.1186/1471-2415-7-3.

Researchers predict age-related macular degeneration (AMD) will increase substantially by 2050, as the U.S. population ages, but the use of new and existing therapies can mitigate the effects of the condition.

A significant preventative therapy named in this study is the use of antioxidant vitamins to slow the progression of AMD from early to late stages.  Other treatments reviewed include laser and photodynamic therapies and anti-VEGF injections.

Scientists from the Research Triangle Institute International in North Carolina simulated cases of early AMD, choroidal neovascularization (CNV), geographic atrophy (GA), and AMD-attributable visual impairment and blindness with 5 universal treatment scenarios:

1. no treatment;
2. focal laser and photodynamic therapy (PDT) for CNV; 
3. vitamin prophylaxis at early-AMD incidence with focal laser/PDT for CNV; 
4. no vitamin prophylaxis followed by focal laser treatment for extra and juxtafoveal CNV and anti-vascular endothelial growth factor treatment; and 
5. vitamin prophylaxis at early-AMD incidence followed by CNV treatment, as in scenario 4.

From the results of this analysis, the researchers predicted that cases of early AMD will increase from 9.1 million in 2010 to 17.8 million in 2050 across all scenarios, but that existing medical therapies have the potential to reduce the visual impairment and blindness attributable to AMD by as much as 35 percent, translating to 565,000 fewer cases of visual impairment and blindness in 2050.

Learn about good food sources of antioxidants

Read about antioxidant vitamins important in the treatment of macular degeneration

SOURCE:  Forecasting age-related macular degeneration through the year 2050: the potential impact of new treatments, Rein, et al,  Arch Ophthalmol. 2009 Apr;127(4):533-40.

Can something as easy as taking a daily multi-vitamin help prevent cataracts? Researchers believe it can!

An analysis of Age-Related Eye Disease Study (AREDS) data has found that consistent use of a multi-vitamin and mineral supplement may delay the progression of age-related lens opacities.  Lens opacities in the form of cataracts are the leading cause of blindness around the world today.

Of the 4596 participants enrolled in the AREDS cataract trial, approximately two-thirds elected to take a multi-vitamin supplement containing RDA-recommended levels of vitamins and minerals.

Subjects were assessed for development or progression of lens opacities via lens photographs at baseline and at annual visits beginning at year 2.  Statistics were collected on changes in amounts of nuclear, cortical, or posterior subcapsular opacity, or the performance of cataract surgery.

Researchers found the risk of development of or progression to any cataract was reduced by 16% in regular multi-vitamin takers. For nuclear cataract, a 25% risk reduction was observed in the multi-supplement users.

Read more about cataracts, including recommended vitamins and supplements

SOURCE:  “Centrum Use and Progression of Age-Related Cataract in AREDS”, AREDS Research Group, Ophthalmol 113:1264-0, 2006.

Researchers studied food and vitamin/mineral supplement consumption of adults in the United States in an effort to measure whether older adults were consuming enough nutrients.

In this study, 4,384 adults aged 51 years and older were evaluated.  1,777 reported taking supplements daily, 428 took them infrequently, and 2179 did not take daily supplements.  Nutrient intake distributions were estimated using the Iowa State University Method.

The results? 

Overall, less than 50% of adults evaluated met the Estimated Average Requirement (EAR) for folate, vitamin E, and magnesium from food sources alone.

Of those who were taking supplements, 80% or more met the EAR for vitamins A, B-6, B-12, C, and E; folate; iron; and zinc, but not magnesium.  However, it was noted that some supplement users, particularly men, exceeded Tolerable Upper Intake Levels for iron and zinc and a small percentage of women exceeded the Tolerable Upper Intake Level for vitamin A.

The researchers concluded that a large proportion of older adults do not consume sufficient amounts of many nutrients from foods alone. Supplements can help compensate for this deficiency, but only an estimated half of this population uses them daily.

Learn tips for taking vitamins and maintaining good digestion

Read about good food sources for nutrients

SOURCE: “Older adults who use vitamin/mineral supplements differ from nonuser in nutrient intake adequacy and dietary attitudes”, Sebastian, et al, Journal of the American Dietetic Assoc 107(8):1322-32, 2007.